Research Interests
In our lab, we are a multidisciplinary team of biologists and chemists in close collaboration with clinicians, radiochemists, physicists and engineers working on a wide variety of research questions in the field of Molecular Imaging and Theranostics. Our goal is the development and clinical translation of molecular imaging and therapy tools for improved tumor detection, intraoperative delineation, patient stratification, treatment optimization and treatment monitoring.We are embedded in the research environment at TranslaTUM and the Nuclear Medicine Department, which allows us to utilize a diverse methodologic portfolio encompassing but not limited to organic synthesis, radiolabeling, HPLC, mass spectrometry, cell culture, in vitro characterization of new tracers, molecular biology e.g. protein expression analysis, confocal microscopy, animal model development, in vivo imaging of new tracers using PET, SPECT and optical imaging, autoradiography and histology. We are employing a growing number of targets for imaging and therapy (=theranostic) applications, including extracellular targets, such as integrins, PSMA, SSTR2 and intracellular targets, e.g. the DNA repair enzyme PARP1.
Application - Open Positions
Currently, we do not have any open Postdoc or PhD positions. Applications from talented and motivated postdocs are always welcome. Please send your CV, list of publications and briefly describe your research interests and experience via email to Prof. Kossatz(link sends e-mail). Postdocs are expected to apply for stipends and fellowships. We will support you in the application process!
We are always looking forward to highly motivated students to conduct internships (6-10 weeks), Master theses and medical doctoral theses in our lab. If you are interested in an applied, interdisciplinary project, you are self-motivated, curious, organized and willing to spend a few months in the lab, please send a CV and motivation letter to Prof. Kossatz (link sends e-mail)via Email.
Prof. Dr. Susanne Kossatz
Tenure Track Assistant Professor, Director of Research Group Imaging & Biomarkers in Oncology
Contact
Tel +49 (89) 4140 9134E-Mail (link sends e-mail)S.Kossatz@tum.de(link sends e-mail)
2021
Quigley NG, Steiger K, Hoberück S, Czech N, Zierke MA, Kossatz S, Pretze M, Richter F, Weichert W, Pox C, Kotzerke J, Notni J. PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the “Cancer Integrin” αvβ6 with Ga-68-Trivehexin. European Journal of Nuclear Medicine and Molecular Imaging 2021 (online ahead of print 09/24/21). PMID: 34559266(link is external).
Demetrio de Souza Franca P*, Kossatz S*, Brand C, Zanoni DK, Roberts S, Guru N, Adilbay D, Mauguen A, Mayor CV, Weber WA, Schöder H, Ghossein RA, Ganly I, Patel SG, Reiner T. A phase I study of a PARP1-targeted topical fluorophore for the detection of oral cancer. *contributed equally. European Journal of Nuclear Medicine and Molecular Imaging 2021 (online ahead of print 05/05/21). PMID: 33954826(link is external).
Ludwig BS, Tomassi S, Di Maro S, Saverio Di Leva F, Benge A, Reichart F, Nieberler M, Kühn FE, Kessler H, Marinelli L, Reuning U*, Kossatz S*. The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins. *contributed equally. Biomaterials 2021; 271: 120754. PMID: 33756215(link is external).
Ludwig BS, Kessler H, Kossatz S*, Reuning U*. RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field. *contributed equally. PMID: 33916607. Cancers 2021; 13(7): 1711. PMID: 33916607(link is external).
Kossatz S, Notni J. A New Paradigm for Integrins. Der Nuklearmediziner 2021; 44: 1-8.
2020
Demetrio de Souza Franca, Guru N, Kostolansky A, Mauguen A, Pirovano G, Kossatz S, Roberts S, Abrahão M, Patel SG, Park KJ, Reiner T, Jewell E. Poly(ADP-ribose)polymerase1: A potential molecular marker to identify cancer during colposcopy procedures. Journal of Nuclear Medicine 2020, 13:jnumed.120.253575.PMID: 33188153(link is external).
Young RJ, De Souza França PD, Pirovano G, Piotrowski AF, Nicklin PJ, Riedl CC, Schwartz J, Bale TA, Donabedian PL, Kossatz S, Burnazi E, Roberts S, Lyashenko SK, Miller AM, Moss NS, Fiasconaro M, Zhang Z, Mauguen A, Reiner T, Dunphy MP. Preclinical and first-in-human-brain-cancer applications of [18F]poly-(ADP-ribose) polymerase inhibitor PET/MR. Neuro-Oncology Advances 2020, 15(2): vdaa119. PMID: 33392502(link is external).
De Souza França PD, Guru N, Roberts S, Kossatz S, Mason C, Abrahao M, Ghossein RA, Patel SH, Reiner T. Fluorescence-guided resection of tumors in mouse models of oral cancer. Scientific Reports, 2020 10(1), pp.1-14.PMID: 32636416(link is external)
Quigley NG, Tomassi S, Di Leva FS, Di Maro S, Richter F, Steiger K, Kossatz S, Marinelli L, Notni J. Click‐chemistry (CuAAC) trimerization of an αvβ6‐integrin targeting Ga‐68‐peptide: Enhanced contrast for in‐vivo PET imaging of human lung adenocarcinoma xenografts. ChemBioChem 2020, 21(19):2836-2843. PMID: 32359011(link is external).
Kossatz S, Pirovano G, De Souza França PD, Sunny SP, Zanoni DK, Mauguen A, Carney B, Brand C, Shah V, Ramanajinappa RD, Hedne N, Birur P, Sihag S, Ghossein RA, Gonen M, Strome M, Suresh, A, Molena D, Kuriakose MA, Patel SG, Reiner T. Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers. Nature Biomedical Engineering. 2020 Mar;4(3):272-285. PMID: 32165735(link is external)
Pirovano G, Roberts S, Kossatz S, Reiner T. Optical imaging modalities: principles and applications in preclinical research and clinical settings. J Nucl Med 2020 Oct 1; 61(10):1419-27. PMID: 32764124(link is external).
De Souza França PD, Roberts S, Kossatz S, Guru N, Mason C, Zanoni DK, Abrahão M, Schöder H, Ganly I, Patel S, Reiner T. Fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor as a potential alternative to 2-deoxy-2-[18F] fluoro-d-glucose positron emission tomography in oral cancer imaging. Nuclear Medicine and Biology. 2020 Jan 23;84-85:80-87. PMID: 32135475(link is external)
Ambur Sankaranarayanan R, Kossatz S, Weber W, Beheshti M, Morgenroth A, Mottaghy FM. Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes. Journal of Clinical Medicine. 2020 Jul;9(7):2130. PMID: 32640708(link is external)
Pirovano G, Jannetti S, Carter L, Sadique A, Kossatz S, Guru N, De Souza França PD, Maeda M, Zeglis B, Lewis J, Humm J, Reiner T. Targeted brain tumor radiotherapy using an Auger emitter. Clinical Cancer Res. 2020 Jun 15;26(12:2871-2881. PMID: 32066626(link is external)
2019
Gonzales J, De Souza França PD, Jiang Y, Pirovano G, Kossatz S, Guru N, Yarilin D, Agwa AJ, Schroeder CI, Patel SG, Ganly I, King GF, Reiner T. Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide. Bioconjug Chem. 2019 PMID: 31647222(link is external).
Laird J, Lok BH, Carney B, Kossatz S, de Stanchina E, Reiner T, Poirier JT, Rudin CM. Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts. J Thorac Oncol. 2019 Oct;14(10):1743-1752. PMID: 31195178(link is external).
Mason C, Kossatz S, Carter L, Pirovano G, Brand C, Guru N, Pérez-Medina C, Lewis JS, Mulder W, Reiner T. A 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor. J Nucl Med. 2019 PMID: 31420495(link is external).
Hernandez Vargas S, Kossatz S, Voss J, Ghosh SC, Tran Cao HS, Simien J, Reiner T, Dhingra S, Fisher WE, Azhdarinia A. Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery. Clin Cancer Res. 2019 Jul 15;25(14):4332-4342. PMID: 31015345(link is external).
Roberts S, Strome A, Choi C, Andreou C, Kossatz S, Brand C, Williams T, Bradbury M, Kircher MF, Reshetnyak YK, Grimm J, Lewis JS, Reiner T. Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer. Sci Rep. 2019 Jun 12;9(1):8550. PMID: 31189972(link is external).
Touijer KA, Michaud L, Alvarez HAV, Gopalan A, Kossatz S, Gonen M, Beattie B, Sandler I, Lyaschenko S, Eastham JA, Scardino PT, Hricak H, Weber WA. Prospective Study of the Radiolabeled GRPR Antagonist BAY86-7548 for Positron Emission Tomography/Computed Tomography Imaging of Newly Diagnosed Prostate Cancer. Eur Urol Oncol. 2019 Mar;2(2):166-173. PMID: 31017093(link is external).
2018
Braza MS, van Leent MM, Lameijer M, Sanchez-Gaytan BL, Arts RJ, Pérez-Medina C, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. Inhibiting inflammation with myeloid cell-specific nanobiologics promotes organ transplant acceptance. Immunity, 2018, Nov 20;49(5):819-828.e6. PMID: 30413362(link is external).
Gonzales J, Kossatz S, Roberts S, Pirovano G, Brand C, Perez-Medina C, Donabedian P, De La Cruz M, Mulder W, Reiner, T. Nanoemulsion based delivery of fluorescent PARP inhibitors in mouse models of small cell lung cancer. Bioconjugate Chemistry, 2018, 29 (11), 3776-3782. PMID: 30354077(link is external).
Donabedian PL, Kossatz S, Engelback JA, Jannetti SA, Carney B, Young RJ, Weber WA, Garbow JR, Reiner T. Discriminating Radiation Injury from Recurrent Tumor with [18F]PARPi and Amino Acid PET in Mouse Models. European Journal of Nuclear Medicine and Molecular Imaging Research. EJNMMI research, 2018, 8(1), 59. PMID: 29974335(link is external).
Kossatz S*, Carney B, Farley C, Drain CM, Weber WA, Reiner T. Direct imaging of drug distribution and target engagement of the PARP inhibitor rucaparib. Journal of Nuclear Medicine, 2018, 59 (8), 1316-1320. *corresponding author. PMID: 29572258(link is external).
Jannetti, SA, Carlucci G, Carney B, Kossatz S, Shenker L, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gonen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T. PARP1-targeted radiotherapy in mouse models of glioblastoma. Journal of Nuclear Medicine, 2018, 59 (8), 1225-1233. PMID: 29572254(link is external).
Carney B, Kossatz S, Lok BH, Schneeberger V, Gangangari KK, Pillarsetty N, Weber WA, Rudin CM, Poirier JT, Reiner T. Target Engagement Imaging of PARP Inhibitors in Small Cell Lung Cancer. Nature Communications, 2018, Jan 12;9(1):176. PMID: 29330466(link is external).
2017
Kossatz S, Weber WA, Reiner T. Commentary: Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Molecular Imaging, 2017, Jan-Dec; 16:1536012117723786. PMID: 28856922(link is external).
Carney B*, Kossatz S*, Reiner T. Molecular Imaging of PARP. Journal of Nuclear Medicine, 2017, Jul 1;58(7):1025-30. PMID: 28473593(link is external). *contributed equally
Büchel GE, Kossatz S, Sadique A, Rapta P, Zalibera M, Bucinsky L, Komorovsky S, Telser J, Eppinger J, Reiner T, Arion VB. cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339. Dalton Transactions, 2017, Sep 12;46(35):11925-11941. PMID: 28850133(link is external).
Tang J, Salloum D, Carney B, Brand C, Kossatz S, Sadique A, Weber WA, Wendel HG, Reiner T. A Targeted PET Imaging Strategy to Differentiate Malignant from Inflamed Lymph Nodes in Diffuse Large B-Cell Lymphoma. Proceedings of the National Academy of Sciences, 2017, 201705013. PMID: 28827325(link is external).
Ghosh SC, Hernandez Vargas S, Rodriguez M, Kossatz S, Voss J, Carmon KS, Reiner T, Schonbrunn A, Azhdarinia A. Synthesis of a Fluorescently Labeled 68Ga-DOTA-TOC Analog for Somatostatin Receptor Targeting. ACS Medicinal Chemistry Letters, 2017, Jun 6;8(7):720-725. PMID: 28740605(link is external).
Kossatz S, Carney B, Schweitzer ME, Carlucci G, Miloushev V, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Research, 2017, 77.8: 2112-2123. PMID: 28108511(link is external).
2016
Kossatz S, Brand C, Gutiontov S, Liu JTC, Lee N, Gonen M, Weber WA, Reiner T. Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Nature Scientific Reports, 2016, 21371. PMID: 26900125(link is external).
Kossatz S, Weber AW, Reiner T. Optical Imaging of PARP1 in response to radiation in Oral Squamous Cell Carcinoma. PloS one, 2016, 11.1: e0147752. PMID: 26808835(link is external).
A complete list of publications can be found here:
MyNCBI(link is external) or Google Scholar(link is external)
| Experimentelle Medizin | PostDoc | PhD Students | Master Students | Translationale Medizin | Dr. med. candidate | Office |
|---|---|---|---|---|---|---|
Nghia Trong Nguyen Lena Koller Tim Rheinfrank Beatrice Stefanie Ludwig |
Carolin Kitzberger Stefan Stangl |
Anna Weber |
Nuzhat Zahin Li Ying Huang Clara Ansel |
Rebecca Wöhr |
Yu Min Anna Hambarzumjan Harmut Rauch |
Thorsten Geerken |
Coming soon..